Syprine
About Syprine:
- Syprine is indicated in the treatment of patients with Wilson’s disease who are intolerant to penicillamine.
- Wilson’s disease is a rare condition where the body stores excess copper.
- Unlike penicillamine, Syprine is not recommended to treat cystinuria rheumatoid arthritis, or biliary cirrhosis.
- Syprine and penicillamine are not interchangeable but is should be used when treatment with penicillamine is no longer possible because of intolerance or side effects.
- Unlike penicillamine, Syprine is not recommended for cystinuria or rheumatoid arthritis.
Strength: Trientine hydrochloride is available in 250 mg capsules
Recommended Dosage:
- The initial dose of Syprine is recommended to be 500-750 mg/day for pediatric patients and 750-1250 mg/day for adults given in divided doses of two, three, or four times daily.
- This may be increased to a maximum dose of 2000 mg/day for adults or 1500 mg/day for pediatric patients aged 12 or under.
- The daily dose of Syprine is increased only when the clinical response is not adequate or the concentration of free serum copper is continuously above 20 mcg/dL.
- Optimal long-term maintenance dosage should be given at 6 to 12-month intervals.
- Syprine should be given on an empty stomach, at least one hour before meals or two hours after meals, and at least one hour gap should be maintained between any other drug, food, or milk intake.
- The capsules should be swallowed whole with water and should not be opened or chewed.
Warnings & Precautions:
- Patients receiving Syprine should remain under regular medical supervision throughout the drug administration.
- Patients should be closely monitored for evidence of iron deficiency anemia, and hypersensitivity.
- Syprine should be taken on an empty stomach, at least one hour before meals or two hours after meals, and at least one hour apart from any other drug, food, or milk.
- This will permit maximum absorption and reduce the chance of inactivation of the drug by metal binding in the gastrointestinal tract.
Common Syprine Side Effects
- Iron deficiency
- Systemic lupus erythematosus
- Dystonia
- Muscular spasm
- Myasthenia gravis
Use in Specific Population
- Pregnancy: There are no adequate and well-controlled studies in pregnant women. Syprine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
- Lactation: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Syprine is administered to a nursing mother.
- Pediatric use: Controlled studies of the safety and effectiveness of Syprine in pediatric patients have not been conducted. It has been used clinically in pediatric patients as young as 6 years with no reported adverse experiences.
Storage and Handling
- Keep the container tightly closed.
- Store at 2° to 8°C (36° to 46°F)
For the medicine procurement, we follow a simple four-step process.
- Enquiry about the medicine: When you request information about the medication you require, we will handle your data. Our Named Access Program Support team will contact you within 24 hours to assist.
- Verification Process: In our mission to help patients access medications that may not be approved or readily accessible in their home countries, Sansfro ensures the verification of medicine availability and approval. Additionally, we thoroughly review the patient’s prescription and medical information for accuracy and compliance.
- Sourcing the Medicine: Upon successfully completing the verification process, our team will initiate contact with our network of suppliers to source the required medication for you. Subsequently, our team works diligently to obtain the most favorable quotes for your medicines and oversees the processing of your order.
- Safe Delivery: We will coordinate the secure delivery of your consignment upon approval of the final quote. Our team of logistics specialists is available to provide consignment tracking assistance. Acknowledging that the Named Access Program industry is susceptible to unauthorized channels is essential. To uphold the safe and legal provision of medications, we rigorously adhere to Standard Operating Procedures.
For the importation of medication, we will require the following documents from the patient:
- An authentic prescription copy.
- A proof of identity document.
- Information about the healthcare provider in charge.
- A current residential address.
Once all these documents are provided, the Sansfro team will begin the import license application process. This license is a crucial requirement to facilitate the procurement of the necessary medication upon receiving government approval.
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About Sansfro
Sansfro is committed to bridging the healthcare gap. Our purpose is to bring hope and healing to patients suffering from rare diseases by linking them with life-saving treatments through our Named Patient Program. Join us in our quest for a better and healthier world.
Know More...FAQ'S
What is Wilson’s disease?
Wilson’s disease is an autosomal inherited metabolic defect that leads to an inability to maintain a near-zero balance of copper. Excess copper accumulates because the liver lacks the mechanism to excrete copper into the bile. Hepatocytes store excess copper but when their capacity is exceeded copper is released into the blood and is taken up into extrahepatic sites. This condition is treated by maintaining a low copper diet following by use of chelating agents that bind copper to facilitate its excretion from the body.
What are the indications and usage of Syprine?
Syprine is indicated in the treatment of patients with Wilson’s disease who are intolerant to penicillamine. Wilson’s disease is a rare condition where the body stores too much copper.
Are there any specific warning or precautions while taking Syprine?
- Patients receiving Syprine should remain under regular medical supervision throughout the period of drug administration.
- Patients should be closely monitored for evidence of iron deficiency anemia, and hypersensitivity.
- Syprine should be taken on an empty stomach, at least one hour before meals or two hours after meals, and at least one hour apart from any other drug, food, or milk.
- This permits maximum absorption and reduces the likelihood of inactivation of the drug by metal binding in the gastrointestinal tract.
What are the most common adverse effects of Syprine?
The following adverse reactions have been reported with trientine hydrochloride: iron deficiency, systemic lupus erythematosus, dystonia, muscular spasm, and myasthenia gravis.
What is the active ingredient of Syprine?
Trientine hydrochloride is the active ingredient of Syprine.
What is the cost of Syprine in India?
For syprine cost and info on availability please contact team sansfro on +91 9315705373 or help@sansfro.com
Dr Anchal Aryan
Medical counselor
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