Zurampic

About Lesinurad(Zurampic)   

• Lesinurad is a prescribed treatment for adult patients with gout who have not achieved adequate reduction in serum uric acid levels with a xanthine oxidase inhibitor alone.
• It is suitable for those individuals with uncontrolled gout symptoms and elevated uric acid levels, addressing the need for additional therapy to manage this condition effectively.
• This medicine should not be taken without a xanthine oxidase inhibitor such as allopurinol or febuxostat.
• Patients are selected based on their medical history, diagnosis, and the recommendation of their healthcare provider to incorporate Lesinurad into their gout management plan.

Strength:

Bottles of 5, 90, and 30 Lesinurad tablets are delivered in a strength of 200mg, respectively, for oral consumption.

Recommended Dosage:

The Lesinurad tablets should be taken at the same time each day until the prescribed treatment duration is completed or as directed by a healthcare professional. These tablets must not be crushed, chewed, or split; instead, they should be swallowed whole. Zurampic tablets can be taken with or without food, depending on individual preference and any specific guidance provided by your doctor.

• The recommended dose of Lesinurad depends on several factors, including the patient’s age, kidney function, and other medications they are taking.
• Avoid taking Lesinurad to patients taking daily allopurinol doses of less than 300 mg.
• For patients with an estimated creatinine clearance (eCLcr) less than 60 mL/min, the recommended allopurinol dose threshold is less than 200mg.
• Ensure that Lesinurad is taken at the same time as the morning dose of the xanthine oxidase inhibitor.
• If there is any interruption in the xanthine oxidase inhibitor treatment, discontinue using Lesinurad.

Important: Patients must consult their treating doctor in case of experiencing any severe side effects, such as allergic reactions. If you forget to take your morning dose of Zurampic tablet, do not take it later in the day. Instead, wait and take it the following morning with your xanthine oxidase inhibitor, like allopurinol or febuxostat. Do not take two doses of Zurampic to compensate for the missed one.

Warnings & Precautions

• Lesinurad is associated with a higher risk of acute renal failure, especially when used without a xanthine oxidase inhibitor.
• This risk is elevated in patients with impaired kidney function.
• Use Lesinurad cautiously in patients with renal impairment.
• Discontinue if estimated creatinine clearance (eCLcr) falls persistently below 45 mL/min.
• Lesinurad can raise the risk of gout flares, particularly when starting therapy.
• Consider gout flare prophylaxis when initiating Zurampic.
• Do not use Lesinurad in patients with severe renal impairment (eCLcr less than 30 mL/min), end-stage renal disease, kidney transplant recipients, or dialysis patients.
• Do not take Lesinurad if you have a rare inherited condition called as Lesch Nyhan syndrome (caused by a mutation in the HPRT1 gene).
• Use with caution in patients taking CYP2C9 inhibitors or in CYP2C9 poor metabolizers.
• Exercise caution in patients with a history of hypersensitivity to Lesinurad or its components.
• Be cautious when using Lesinurad in pregnant or breastfeeding women.
• Use with caution in patients operating vehicles or machinery, as it may cause dizziness and fatigue.

Common Lesinurad Side Effects

• Acute renal failure
• Stevens-Johnson syndrome
• Toxic epidermal necrolysis
• Nausea
• Vomiting
• Diarrhea
• Headache
• Dizziness
• Gout flares
• Increased liver enzymes
• Kidney stones
• Hypersensitivity reactions

Use in Specific Population

Limited data exist for those aged 75 and older. No dosage adjustment is needed for those aged 65 and older, but they may have reduced renal function, so refer to renal impairment dosing recommendations. It is unknown about the safety and effectiveness of Lesinurad in individuals under the age of 18.

Storage and Handling

Store at 20°C to 25°C.