Optimizing Gout Management: Zurampic’s Role in Lowering Uric Acid Level

Gout is a type of arthritis caused by the buildup of uric acid crystals in the joints, leading to inflammation and pain. Hyperuricemia, or high levels of uric acid in the blood, is a major risk factor for gout. Zurampic (Lesinurad) is a medication that can be combined with a xanthine oxidase inhibitor (XOI) to treat hyperuricemia associated with gout in patients who have not achieved target levels of serum uric acid. 

Mechanism 

Zurampic works by inhibiting the urate transporter, URAT1, which is responsible for the majority of the renal reabsorption of uric acid. By inhibiting URAT1, Zurampic increases uric acid excretion and thereby lowers serum uric acid (sUA).

Dosage Condition

Zurampic is not recommended for patients who have not yet reached target levels of serum uric acid or who have frequent gout flare-ups or tophi. It is also much more expensive than other uricosuric agents such as probenecid. 

Zurampic should be used in patients who are already taking appropriate doses of a xanthine oxidase inhibitor such as allopurinol. The dosage of Zurampic is 200 mg once daily, taken with food and water at the same time as the XOI.

Zurampic has been shown to be an effective and safe treatment option for gout patients who have not achieved target levels of serum uric acid. However, it can cause acute renal failure if taken without a xanthine oxidase inhibitor, at a higher dose than recommended, or in patients with severe renal impairment. Zurampic should not be initiated in patients with an estimated creatinine clearance (eCLcr) of less than 45 mL/min, and more frequent renal function monitoring is recommended in patients with an eCLcr below 60 mL/min.

For individuals seeking to buy Zurampic online, exclusively available in the US and Europe, Sansfro Health provides a trustworthy option. Devoted to simplifying the importation process, Sansfro Health delivers accurate pricing information for a seamless experience. Sansfro facilitates the importation with genuine pricing and comprehensive support.

Patients interested in importing medication are required to provide a valid prescription, identity proof, healthcare professional details, and current address. The Sansfro team initiates the application for an import license, ensuring access to the necessary medication upon government approval. To inquire about the price of Zurampic in India and understand the importation procedure, individuals can contact the Patient Support Team at (+91) 93157 05373 or via email at help@sansfro.com. 

Reference

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207988lbl.pdf 
2. https://www.aafp.org/pubs/afp/issues/2018/0315/p374.html 
3. https://www.astrazeneca.com/media-centre/press-releases/2015/ZURAMPIC-lesinurad-approved-by-US-FDA-for-patients-with-gout-22122015.html 
4.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544139/ 
5.  https://pubmed.ncbi.nlm.nih.gov/28425024/ 
6. https://www.ncbi.nlm.nih.gov/books/NBK537366/