Understanding Tucatinib: Mechanism Of Action And Its Impact on Breast Cancer Cells

Tukysa (tucatinib) is a targeted therapy medication used to treat certain advanced-stage HER2-positive breast cancers. It is a tyrosine kinase inhibitor that works by blocking the HER2 protein, which is found in some breast cancer cells, and stimulates them to grow. By inhibiting the HER2 protein, Tucatinib helps control cell growth and division, preventing breast cancer cells from growing and spreading.

How Tucatinib Works?

1. Targeting HER2: Tucatinib targets the HER2 protein, which is found on some breast cancer cells, and stimulates them to grow. By binding to HER2, Tucatinib inhibits its tyrosine kinase activity, blocking the signaling pathways that lead to cell growth and division.

2. Combination Therapy: Tukysa/Tucatinib is given in combination with two other cancer drugs: trastuzumab (Herceptin) and capecitabine (Xeloda). This combination therapy enhances the effectiveness of tucatinib in treating HER2-positive breast cancer.

Dosing And Administration

• Tukysa (Tucatinib) tablets are designed for oral use and are available in two strengths, 50 mg and 150 mg. 
• The recommended dosage is 300 mg, to be taken orally twice daily, with or without food. 
• In cases of severe hepatic impairment, it is advised to take a recommended dosage of 200 mg orally twice daily.

Impact on Breast Cancer Cells

Tukysa has demonstrated significant effectiveness in treating HER2-positive breast cancer, particularly in patients who have already received one or more anti-HER2 treatments. In a clinical study called HER2CLIMB, more people responded to treatment with Tukysa compared to those who did not receive the treatment. Additionally, Tukysa has an additive anti-tumor effect when used with the chemotherapy drug capecitabine (Xeloda).

For those seeking to buy Tucatinib online, exclusively available in the US and Europe, Sansfro Health is a reliable option. Committed to streamlining the importation process, Sansfro Health provides accurate pricing information for a seamless experience. Sansfro facilitates the importation with authentic pricing and comprehensive assistance. 

Individuals interested in importing medication must provide a valid prescription, identity proof, healthcare professional details, and current address. The Sansfro team initiates the import license application, ensuring access to the necessary medication upon government approval. For inquiries about the Tucatinib price in India and to understand the importation procedure, individuals can contact the Patient Support Team at (+91) 93157 05373 or via email at help@sansfro.com. 

Reference:

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/213411s004lbl.pdf
2. https://www.breastcancer.org/treatment/targeted-therapy/tukysa 
3. https://www.medicalnewstoday.com/articles/tukysa 
4. https://breastcancernow.org/about-breast-cancer/treatment/targeted-biological-therapy/tucatinib-tukysa/ 
5. https://www.tukysa.com/mbc/what-is-tukysa